The retinoic acid receptor beta (RARB) gene (Gene ID: 5915) is located on the short (p) arm of chromosome 3 (3p24.2). It consists of 13 exons, four promoter regions and has a size of 423 kb in humans. RARB encodes retinoic acid receptor beta (RAR-beta), which belongs to the retinoic acid receptor family together with the other sub-types RAR-alpha and RAR-gamma.
RAR-beta is a nuclear receptor and transcription factor. Upon activation by retinoic acid (the biologically active form of vitamin A), it regulates the expression of a plethora of genes in the human body. It plays a pivotal role in the development of the embryonic digestive tract, eye, myogenesis, and brain (especially the striatum). Furthermore, RAR-beta is a tumor suppressor and hence has been in the focus of cancer therapy for almost two decades.
Further, more detailed information on the RARB gene and RAR-beta protein can be found in following pages: